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  • 19 Jan 2016 9:44 AM | ISDE Membership (Administrator)

    “Refractory GERD: a complicated puzzle”

    The persistence of symptoms in GERD patients despite adequate PPI therapy is a rather common and sometimes frustrating problem. Two articles in this January issue of Diseases of the Esophagus deal with this topic, offering some insight on the mechanisms underlying the condition.

    In the first article by Mandalyia et al (Survey of findings in patients having persistent heartburn on PPI therapy), 100 patients with GERD symptoms refractory to PPI were assessed by means of combined impedance-pH study and the Symptom Sensitivity Index (SSI). Patients were then  divided into 4 groups on the basis of these findings, i.e.  cases with acid reflux, those with non-acid reflux, those with a positive SSI and those with normal reflux parameters; the Authors suggested that the normal treatment strategy of increasing the PPI dose when patients remain symptomatic might only be appropriate for some patients.

    In the second study by DeBortoli et al. (Lower pH value of weakly acidic refluxes as determinants of heartburn perception in GERD patients with normal esophageal acid exposure), the Authors focused on patients  with  a positive Symptom Association Probability (SAP) index and Symptom Index for weakly acidic reflux, finding that a lower nadir pH (in the range of pH 4 to 5.5) during non-acid reflux was associated with symptom perception, suggesting that a higher concentrations of hydrogen ions may be an important symptom trigger, even for “non-acid” reflux in this complex condition.

  • 19 Jan 2016 9:09 AM | Anonymous

    Click here to read the full Esophagram.

  • 19 Jan 2016 6:30 AM | Anonymous

    click here for more information

  • 18 Jan 2016 8:25 AM | Anonymous

    Read the new presidential message from our ISDE president. 

  • 11 Jan 2016 10:26 AM | Anonymous

    For members only - click here to get to the members only area.

  • 07 Jan 2016 8:36 AM | Anonymous

    Visit our literature updates area to find out the latest literature related to esophagus.

  • 07 Jan 2016 8:35 AM | Anonymous

    We wish all our members, partners and stakeholders all the best for the new year!

  • 09 Dec 2015 9:44 AM | ISDE Membership (Administrator)

    Inter-observer agreement for diagnostic classification of esophageal motility disorders defined in high-resolution manometry

    by Mark Fox et al.

    High resolution manometry is widely accepted in the clinical practice and is now considered the “golden standard” to diagnose esophageal motor disorders.  The inter-observer agreement of this test was not yet validated, however. In this article Mark Fox and colleagues asked 18 pratictioners from 13 institutions to analyze individual water swallows and 36 practitioners from 28 institutions to assess 40 diagnostic studies. Consensus agreement was found in most of normal peristalsis and in achalasia, but not for cases of peristaltic dysmotility.  In clinical studies the agreement among the assessors was substantial for achalasia type I/II, but fair to moderate for any diagnosis. The Authors suggest that in clinical practice diagnostic performance should be based not only on pattern recognition of HRM images, but also on quantitative metrics of contractile and intrabolus pressures that provide an obiective diagnosis of esophageal motor abnormalities.

    Giovanni Zaninotto,
    Editor in Chief
    Diseases of the Esophagus

    for more information - click here.

  • 09 Dec 2015 8:46 AM | Anonymous

    The 2015 ESDE meeting was held at the Sheraton hotel in Stockholm November 5 – 7. The meeting started with two parallel precourses; one surgical featuring minimal invasive esophagectomy and the other endoscopic with focus on endoscopic mucosal resection techniques and peroral endoscopic myotomy (POEM). Both precourses were very lively and interactive, featuring live procedures broadcasted from the Karolinska and Ersta hospitals to the downtown venue at the Sheraton Hotel.

    The opening ceremony session, after the precourses, included state of the art presentations and an honorary membership ceremony in which Professor Lars Lundell, host of the 2003 ESDE meeting in Göteborg, was awarded a honorary membership. The first day of the meeting was wrapped up with a welcome reception at the Stockholm City Hall, the venue of the Nobel Prize dinner banquet held annually on December 10th.

    On November 6th, the main day of the event, several highly interesting sessions were held, focusing on new frontiers in oesophagology, enhanced recovery after esophagectomy, benign esophageal diseases, lymph node dissection and a neoadjuvant therapy session endorsed by ESTRO. There were also oral presentations of original work and poster sessions. At the ESDE societal affairs meeting a new board was elected for the society, with Manuel Pera leaving way as president for Peter Siersema, Christophe Mariette staying on as financial officer and Magnus Nilsson being elected as General Secretary. The icing on the cake was the main social event for the whole meeting, the Gala Dinner at Soliden, at the outdoor museum of Skansen.

    The last day of the 2015 ESDE meeting, Saturday November 7th, featured several very interesting topics. The first session of this day was Controversies in oesophagology, with medical debates on various hot and controversial topics. This was followed by the first trainee chapter session in the history of the ESDE, taking the form of a Dragon’s den session with trainees proposing study ideas before a den of “dragons”, experienced academic oesophagologists and a biostatistician, critically discussing the proposals. The last session of the entire 2015 ESDE meeting was the Top of the crop: selected oral presentations session with the top five abstracts presented and then the award of best abstract of the meeting. Winner of the award was home player Fredrik Klevebro, with his abstract on the NeoRes trial.



  • 09 Dec 2015 4:17 AM | Anonymous

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